extracellular matrices การใช้

• They are secreted and incorporated into cell-associated extracellular matrices.
• These fibers with their extracellular matrices contribute to the viscoelasticity of these tissues.
• In vertebrates, fibulin-1 is found in blood and extracellular matrices.
• They form major structural elements in extracellular matrices of cartilage, skin, and tendon.
• One area of research featuring nanobiotechnology is the extracellular matrices of cells ( ECM ).
• Heparan sulphate proteoglycans ( HSPGs ) play a key role in the self-assembly, insolubility and barrier properties of basement membranes and extracellular matrices.
• Diverse glycoproteins of cell surfaces and extracellular matrices, operationally termed as'adhesion molecules'are important in the specification of cell interactions during development as well as maintenance and regeneration of the nervous system.
• By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, noggin may have a principal role in creating pleiotropic effects, both early in development as well as in later stages.
• Scientific advances in biomaterials, stem cells, growth and differentiation factors, and biomimetic environments have created unique opportunities to fabricate tissues in the laboratory from combinations of engineered extracellular matrices ( " scaffolds " ), cells, and biologically active molecules.
• Along with its role in the regulation of normal mineralization within the extracellular matrices of bones and teeth, OPN is also upregulated at sites of pathologic, ectopic calcification  such as for example, in urolithiasis and vascular calcification  presumably at least in part to inhibit debilitating mineralization in these soft tissues.
• While it is abundant in extracellular matrices, hyaluronan also contributes to tissue hydrodynamics, movement and proliferation of cells, and participates in a number of cell surface receptor interactions, notably those including its primary receptors, CD44 and RHAMM . Upregulation of CD44 itself is widely accepted as a marker of cell activation in lymphocytes.
• Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices . [ provided by RefSeq, Aug 2011 ] . # # Evidence-Data-START # # Transcript exon combination : : AY120869.1, BC103895.1 [ ECO : 0000332 ] RNAseq introns : : single sample supports all introns ERS025087, ERS025091 [ ECO : 0000348 ] # # Evidence-Data-END ##